• Effects of positive end-expiratory pressure on cerebral hemodynamics in acute brain injury patients 

      Giardina, Alberto; Cardim, Danilo; Ciliberti, Pietro; Battaglini, Denise; Ball, Lorenzo; Kasprowicz, Magdalena; Beqiri, Erta; Smielewski, Peter; Czosnyka, M.; Frisvold, Shirin Kordasti; Grosnik, Matjaz; Pelosi, P.; Robba, Chiara (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-02)
      Background: Cerebral autoregulation is the mechanism that allows to maintain the stability of cerebral blood flow despite changes in cerebral perfusion pressure. Maneuvers which increase intrathoracic pressure, such as the application of positive end-expiratory pressure (PEEP), have been always challenged in brain injured patients for the risk of increasing intracranial pressure (ICP) and altering ...
    • Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study 

      Beqiri, Erta; Smielewski, Peter; Guérin, Claude; Czosnyka, Marek; Robba, Chiara; Bjertnæs, Lars Jakob; K Frisvold, Shirin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)
      Introduction - Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.<p> <p>Methods ...